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The primary ones are responsible for the development of lymphocytes, such as their maturation and transformation into active cells, while the secondary lymphatic organs allow these cells to function properly

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Transient stress or increased cytoplasmic TDP-43 triggers phase separation into toxic cytoplasmic droplets that block nuclear import, deplete nuclear TDP-43, and cause cell death, offering a present mechanistic model for ALS/FTD pathology (Gasset-Rosa et al., 2019)

However, cyclophosphamide has been employed in developing animal models of interstitial cystitis in in vivo studies