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The peptide was first isolated during experiments in rabbits and named for its reported association with increased electroencephalographic delta activity

[DOI] [PMC free article] [PubMed] [Google Scholar] 277.Liang X., Potter J., Kumar S., Zou Y., Quintanilla R., Sridharan M., Carte J., Chen W., Roark N., Ranganathan S

The protective effect of antioxidants is largely attributed to their ability to scavenge free radicals (126, 243, 254)

Furthermore, MPTP-treated mice exhibited significantly upregulated expression levels of iNOS, TNF, and IL-1 compared to controls, whereas irisin treatment notably attenuated the expression of these pro-inflammatory markers (Fig