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Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

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Preclinical models provide stronger internal validity, showing convergent improvements in oxidativeinflammatory balance, TGFdriven fibrosis, neuromuscular plasticity, and Bax/Bcl2mediated apoptotic control when polyphenols are paired with structured training or rehabilitation, but translational certainty to human oncology remains moderate due to species, dosing, and diseasemodel differences

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