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While GPX4 is a key regulator in detoxifying lipid peroxides, several GPX4-independent mechanisms, such as lipid remodeling by MBOAT1 and MBOAT2 and lipid detoxification by iPLA2, provide additional layers of protection

In contrast, an RCT of 30 older adolescents and adults (mean age of entry: 30 years) with a genetic mitochondrial disease who were exposed to the identical DCA dose and dose schedule employed in the pediatric trial was stopped prematurely because of worsening or new onset of peripheral neuropathy [31] , a common complication of mitochondrial diseases [32,33]

The solution structure of the bacterial HSP70 chaperone protein domain DnaK (393-507) in complex with the peptide NRLLLTG