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Pomegranate supplementation led to significant reductions in systolic blood pressure (MD: -0.47, 95% CI [-0.58, -0.36], p= 0.00001), fasting serum glucose (MD: -6.20, 95% CI [-8.24, -4.16], p= 0.00001), insulin levels (MD: -1.18, 95% CI [-2.01, -0.35], p= 0.005), triglycerides (MD: -29.33, 95% CI [-57.71, -0.95], p= 0.04), total cholesterol (MD: -18.48, 95% CI [-28.72, -8.23], p= 0.0004), and LDL levels (MD: -10.54, 95% CI [-12.83, -8.25], p= 0.00001), alongside a significant increase in HDL levels (MD: 5.16, 95% CI [3.36, 6.96], p= 0.00001)

Peridomestic Lyme disease prevention: results of a population-based casecontrol study

While several known proteolytic enzymes such as those involved in blood clotting (126) and cancer metastasis (127, 128) have been identified as IGFBP-3 proteases, the identity of the pregnancy protease is still not resolved

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