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To systematically identify 20S proteasome substrates under native conditions, we used an advanced mass spectrometry (MS) approach coupled to biochemical and cellular analysis

2020;318:L77386

Alzheimer disease pathology reduction The most extensive body of P21 research has been conducted in the 3xTg-AD mouse model, a transgenic strain that develops both amyloid-beta plaques and tau tangles, closely mimicking human Alzheimer disease pathology

L-ET is known for its exceptional stability and specificity in scavenging reactive oxygen species (ROS), while GSH plays a broader role in cellular processes, including detoxification and immune function