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Additionally, metabolic reprogramming and oxidative stress form a positive feedback loop: enhanced glycolysis in senescent cells increases mitochondrial ROS accumulation 106,107 , while cancer cells sustain high ROS levels via the Warburg effect, promoting proliferation and inhibiting apoptosis 108

[DOI] [PMC free article] [PubMed] [Google Scholar] 149.Cembrowska-Lech D., Krzemiska A., Miller T., Nowakowska A., Adamski C., Radaczyska M., Mikiciuk G., Mikiciuk M

Treat that value as an estimate

This suggests that Nm serves as a critical regulatory brake, preventing excessive protein expression and ensuring precise control over protein synthesis, degradation, and nuclear export