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Subcutaneous tissue is densely populated with mast cells, and cationic peptides are established activators of the MRGPRX2 receptor on human skin mast cells, triggering degranulation and histamine release through a signalling cascade that has been characterised in some detail in primary human skin mast cells

Two hundred microliters of the sample lysate were added to 1 10 6 cells/mL and thoroughly mixed by pipetting

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The live confocal microscopy images verified the high-level vesicular uptake of the dual-targeted nanocarriers compared to the non-targeted groups in brain endothelial cells (Fig