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A broad panel of antibodies was employed, including those for FOXO4, p53, phospho-p53, p21, p16, cleaved-Caspase3, BAX, BCL-2, testosterone synthesis enzymes (3-HSD, CYP11A1, CYP17A1), and various SASP factors (IL-1, IL-6, TNF-, TGF-)

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The review then outlines the different nanoparticle types, both inorganic and organic, and explores recent scientific advancements related to each category

Research Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models Mu X, Qu L, Yin L, Wang L, Liu X, Liu D (2024, October) This study developed a novel fusion peptide, DSIP-CBBBP, combining delta sleep-inducing peptide (DSIP) with a blood-brain barrier crossing peptide, produced via Pichia pastoris