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Description

Non-clinical studies of progesterone

Collectively, these data demonstrated that 2012.2 are ser/gly synthesis-dependent GBM cells, highlighted by increased serine- and glycine-derived synthesis of nucleotides and GSH, as well as adaptive upregulation of PSPH under hypoxic conditions, which could be efficiently targeted by sertraline treatment

Funding This study was supported by the Canadian Institutes of Health Research (grant number MOP-64345) and in part by the Ontario Ministry of Health and Long Term Care