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Recently, it was demonstrated that in a high-glucose (HG) environment, the tumor suppressor gene BAP1 partially deubiquitinates H2Aub on the SLC7A11 promoter, thereby suppressing transporter function, limiting cysteine uptake, and increasing ferroptosis sensitivity [42]

Additionally, a ketogenic diet can be difficult to adhere to and may have adverse effects on quality of life, particularly in patients who are already dealing with the physical and emotional challenges of cancer treatment

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Recent studies have demonstrated that EMPA exerts direct immunomodulatory effects, particularly through mechanisms that link metabolic regulation to inflammatory signaling