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Evid Based Complement Alternat Med 2013:915691 Brown KD, Farmer C, Freeman GM Jr, Spartz EJ, Farhadian B, Thienemann M, Frankovich J (2017) Effect of early and prophylactic nonsteroidal anti-inflammatory drugs on flare duration in pediatric acute-onset neuropsychiatric syndrome: an observational study of patients followed by an academic community-based pediatric acute-onset neuropsychiatric syndrome clinic

Stimulates the release of endogenous growth hormone and ghrelin

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Interestingly, although increased PHGDH expression supports cancer cell proliferation, studies have demonstrated that low PHGDH induces abnormal protein glycosylation through activation of the hexosamine-sialic acid pathway, thus non-catalytically enhancing cancer spread and metastasis (Rossi et al., 2022)