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According to a recent systematic review, supplementation with vitamin A, C, B12, B3, B6, and D (with or without calcium), multivitamins, selenium, and calcium does not reduce the risk of overall or cardiovascular mortality.78 The US Preventive Services Task Force does not recommend the use of vitamins or multivitamins to prevent cardiovascular disease or cancer.78 Indeed, it advises against beta-carotene supplementation, as there is evidence that it might increase the risk of lung cancer and overall and cardiovascular mortality

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Dysmenorrhea is thought to occur due to the presence of inflammatory prostaglandins and leukotrienes, which contribute to uterine contractions, increased nerve sensitivity, and a lack of muscular blood flow

doi: 10.1182/blood-2014-09-599423 128 LuznikLJallaSEngstromLWIannoneRFuchsEJ