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While protein secretion has long been studied in Gram-negative bacteria, our understanding of the secretion of additional extracellular materials is less complete 28,29,30

FIGURE 2 Succination of GPX4 Succination was discovered in 2006 as a non-enzymatic, irreversible protein modification ( Ubiquitination of GPX4 Ubiquitination is a reversible process in which the ubiquitin is added to lysine residue(s) of the substrate protein by three different types of enzymes, E1, E2, and E3

However, recent work on the CoQ oxidoreductase FSP1 has provided some clear indications that it is the extra-mitochondrial CoQ 10 pool at the plasma membrane that is relevant for ferroptosis protection 7,8

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