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Traditional healers are acknowledged by the government in certain countries, such as South Africa, and are incorporated into the public healthcare system [45]

These collective findings establish the gut microbiome as a key modulator of gout pathogenesis through its metabolites, which act on multiple fronts including regulating purine metabolism, influencing uric acid dynamics, and shaping inflammatory responses

SA treatment induced slight up-regulation of the expression level of GhGPX1 and GhGPX8 , and down-regulation of GhGPX3 (Fig

Sodium penthothal (Laboratorios Abbot, Caracas, Venezuela), was employed intravenously to anesthetize animals