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Initially, these phagocytes adopt a pro-inflammatory, microbicidal program characterized by elevated production of reactive oxygen species (ROS), nitric oxide (NO), proteolytic enzymes, and pro-inflammatory cytokines like IL-1, IL-6, and TNF-, enabling efficient pathogen clearance [39]

Phase I reactions are usually the initial steps in the biotransformation process, generating metabolites that can serve as substrates for Phase II conjugation reactions

Treatment with the CDK9 inhibitor NVP-2 80 , CDK12/13 inhibitor THZ531 81 or CDK7 inhibitor SY-351 75 for 30 min did not reduce P-SF3B1 levels (Fig