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Inhibitors of transporter proteins Many studies have reported that cisplatin can enter cochlear hair cells via various cation transport proteins and MET machinery formed by transmembrane channel-like 1 and 2 (TMC1/2), LHFPL tetraspan subfamily member 5 protein (LHFPL5), transmembrane inner ear protein (TMIE), calcium and integrin-binding family member 2 (CIB2), and tip link proteins (Protocadherin-15 and Cadherin-23) ( A report suggests that the inhibition of MET by quinine or ethylene glycol tetraacetic acid (EGTA) can prevent cisplatin-induced hair cell death (Thomas et al., 2013)

doi: 10.1159/000012183 20 BaderDAMcGuireSE

HP1 Heterochromatin protein 1 (HP1), encoded by the Cbx1 gene, is actively involved in processes like chromatin condensation, transcriptional regulation, and DNA damage repair [105]