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This difference is likely to result in different conformations and possibly different polarities and flexibilities for loop 3

153 SawadaY.ToyookaK.KuwaharaA.SakataA.NaganoM.SaitoK.et al (2009b)

This pathway is considered the most genotoxic as the 4-OH estrogen metabolites can become reactive quinones that have the potential to bind to DNA and form damaging (unstable) depurating adducts, that may increase risk for cancer, such as breast and prostate cancer

Nevertheless, conventional Se formulations such as sodium selenite and methyl selenol are limited by their narrow therapeutic window and dose-dependent toxicity [22]