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Studies have found that under pathological conditions, astrocytes are activated by A to produce cytoinflammatory factors, complement, oxygen free radicals, etc., which then trigger inflammation, promote nerve cell damage and death, and ultimately aggravate Alzheimers disease (Do et al., 2014

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doi:10.1016/S0076-6879(05)01005-0

Fortunately, nanoparticles carrying chemicals or biological materials may assist in overcoming the limitations, which combine ferroptosis inducers and certain antibodies on the surface of nanoparticles and enhance the targeting capacity towards fibrotic tissues while minimizing potential side effects