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A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Paracetamol metabolism pathways and breakdown into Download Scientific Diagram acetaminophen toxicity glutathione step 1 in Children: Diagnosis, Clinical Assessment, and Treatment of Acute Overingestion Pathways for acetaminophen metabolism. Acetaminophen
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