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Autophagy as a regulator of immune tolerance and inflammation Autophagy plays a dual role in autoimmunity by regulating immune cell function, antigen processing, and inflammatory responses

Interestingly, the methylation of the FGF-21 gene declines prior to the onset of overt metabolic abnormalities, suggesting that this epigenetic change may represent an adaptive response by the liver to maintain glucose homeostasis during the early stages of metabolic dysregulation [216]

Endothelial dysfunction is distinguished by reduced NO bioavailability and reduced vasodilation connected to a proinflammatory and prothrombotic condition