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Building upon this evidence, we propose that limited extracellular CAT pool in serum is particularly vulnerable to oxidative modification through direct exposure to APP-derived reactive species, which may account for its diminished activity

Although NO may be released from GSNO in culture, the rate of NO formation is entirely dictated by media conditions and may not be the major mechanism of GSNO decay

4.3 Multifaceted roles of GPXs in plant biological processes The direct association of GPX2, GPX3, GPX4, GPX5, GPX7, and GPX8 with glutathione metabolic processes ( Figure 5 ) suggests that the proteins can use glutathione as an electron donor in reducing H 2 O 2 or organic and lipid hydroperoxides to maintain plant cell redox homeostasis ( Supplementary Table S2 ) (Yang et al., 2005)