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It also requires careful medical supervision and involves substantial cost

In human clinical use, reported side effects are generally mild and transient: Mild injection site redness or discomfort (resolves within hours) Transient nausea in some patients, particularly early in the protocol Mild dizziness or light-headedness (rare, typically dose-related) Temporary fatigue in the first few days (often a sign of active tissue remodeling) No significant systemic toxicity, organ damage, hormonal suppression, or addiction potential has been documented in the published literature

CNS Drugs 2017;31:1057-82

When a man has clinically low testosterone and responds well to treatment, the people closest to him may notice changes in his energy, sexual interest, mood, confidence, and daily habits