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FIGURE 1 There are several examples of drugs becoming toxic/bioactive following their conjugation with GSH

In macrophages, heme is first decomposed to generate biliverdin by heme oxygenase-1 (HO-1), which then undergoes reduction to bilirubin by biliverdin reductase(BVR) (5, 6) ( Figure 1 )

Similarly, the mineral zinc and also B vitamins (especially vitamin B12) are needed for endocrine health and may be missing in your diet, especially if you rarely consume animal foods

After inducing ischemic AKI in 810-week-old, male C57BL/6 mice, mass spectrometry metabolomics revealed that the liver had the most distinct phenotype 24 h after AKI versus 4 h and 7 days