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Unlike NSAIDs, acetaminophen works primarily in the brain and spinal cord rather than throughout the body, which explains why it's effective for pain and fever but doesn't reduce inflammation like NSAIDs do (Li et al., 2013

If the purging lasts longer than six weeks, it may be a sign that the product is not working for your skin, and you should consider stopping it or consulting a dermatologist

These effects are mediated through restoration of gut microbial balance and repair of intestinal barrier integrity, thereby reducing the uremic toxin burden and alleviating cardiovascular and metabolic disorders [184]

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