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Scientific Reports 11 (1): 20499

10.1016/j.survophthal.2020.01.002 10

By wrapping the glutathione molecule in this protective lipid shell, we allow it to bypass the harsh environment of the stomach

This is not surprising since although metformin is the primary biguanide used in the treatment of T2DM, both phenformin and buformin have been demonstrated to negatively affect vitamin B 12 levels