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While the transappendageal pathway, which utilizes appendages such as hair follicles, sweat ducts, and sebaceous glands, constitutes only about 0.1% of the skin surface area (though this percentage may be higher in specific regions such as the forehead) [22], its contribution to percutaneous transport is generally considered secondary

References: Seiwerth, S., Milavic, M., Vukojevic, J., Gojkovic, S., Krezic, I., Vuletic, L

However, due to a lack of significant data, in Phase 1 and Phase 2 clinical trials, the manufacturer decided to stop further trials