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Summary and Recommendations Based on the studies of antioxidant and mucolytics, various respiratory associations and bodies have made the following recommendations: GOLD Executive Summary 2017 44 : Regular treatment with mucolytics such as carbocysteine and N-acetylcysteine may reduce exacerbations and modestly improve health status in patients not receiving inhaled corticosteroids. European Respiratory Society/American Thoracic Society 2017 84 : In COPD with moderate or severe airflow obstruction and exacerbations despite optimal inhaled therapy, we suggest treatment with an oral mucolytic agent to prevent future exacerbations