glutathione synthesis deficiency and heart disease Impaired in Neurodegeneration Glutathione Depletion in Mitochondrial Diseases

2.6.1.5 Effects of SL on liver fibrosis A team of Chinese researchers reported that SL inhibited HSC activation and hepatic apoptosis and prevented the formation of mallory-denk bodies in the NASH liver when SL was orally administered to the male C57BL/6 mice which were fed a MCD diet for 8 weeks, and the effect was related to alteration of lipid metabolism-related gene expression, activation of the Nrf2 pathway and inhibition of the NF-B signaling pathway in the NASH liver (Ou et al., 2018)

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Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model

Kamerkar S, LeBleu VS, Sugimoto H, Yang S, Ruivo CF, Melo SA