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Description

Under oxidative stress conditions, active cysteine residues of Keap1 undergo direct modifications, changing the structure of the active E3 ubiquitin ligase and leading to a breakdown in ubiquitination [23, 24]

doi: 10.1038/srep30033 23 FuDWangCYuLYuR

Current topics of study include the developmental basis of bats' and marsupials' unique phenotypes and the developmental, cellular, and molecular basis of aging in bats

Various methods, including disulfide bonds, thioether bonds, thiol-maleimide bonds, phosphodiester bonds, and click chemistry, are used for this covalent connection