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Description

Examples of representative protective groups for the carboxyl group are esters, such as the tert-butyl ester (tBu), allyl ester (All), triphenylmethyl ester (Trt ester), cyclohexyl ester (cHx), benzyl ester (Bzl), ortho-nitrobenzyl ester, para-nitrobenzyl ester, para-methoxybenzyl ester, trimethylsilylethyl ester, 2-phenylisopropyl ester, fluorenylmethyl ester (Fm), 4-(N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino) benzyl ester (Dmab), among others

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The trial explored subcutaneous single ascending doses (SAD) from 0.031.50 mg/kg and multiple ascending doses (MAD) from 0.753.0 mg/day

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Fluorescence was subsequently recorded and scored for individuals showing luminal dilation

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The body needs vitamin B12 to metabolize proteins and fats properly and to turn carbs into glucose, which is used as fuel

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