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Mycophenolate mofetil and tacrolimus are, among other indications, increasingly being recognized as useful drugs in the treatment of interstitial lung disease in systemic rheumatic diseases and skin fibrosis in systemic sclerosis

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530 Some nanomedicine, especially metal oxide nanoparticles have been reported to modulate mitophagy via affecting critical mitophagy-related proteins

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The smaller size of the His-Tag generally has minimal impact on the proteins function and can be easily removed if necessary

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