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During sample collection an assessment as to whether an individual was affected with konzo was conducted following the WHOs 3 main criteria for diagnosis including evidence of (1) a visible symmetric spastic abnormality of gait while walking or running, (2) a history of onset of less than 1 week followed by a nonprogressive course in a formerly healthy person, and (3) bilaterally exaggerated knee or ankle jerks without signs of disease of the spine

In addition, in vitro studies have shown that recombinant TTR amyloid aggregates are internalized by human cardiac fibroblasts, which subsequently secrete IL-6 and IL-8, providing mechanistic evidence that TTR aggregates can trigger inflammatory responses in cardiac cells [77]

Decoding the relationship between oxidative stress and antiseizure medications using network pharmacology and molecular docking

Lyophilized (freeze-dried) tirzepatide powder Lyophilized tirzepatide is the most stable form