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Estrogen appears to act by preferentially inducing new expression of type III collagen in aged skin, presumably invoking a developmental-type programme of expression [101, 105]

AN can present as a clinical condition linked to various genetic disorders, many stemming from insulin resistance syndromes or FGFR functional abnormalities (3032)

By using a standardized model of the microbiota, a high degree of reproducibility could be achieved ( in vitro , even under the same culture conditions and despite being derived from the same source (47)

However, these analyses were limited to asthma risk and did not focus on the role of these genes in the severity of the disorder