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In that study, supplementation of carnitine, even in high levels, did, however, not restore normal litter sizes

Aside from dietary consumption, approximately 25% of total body carnitine is synthesised by the body from the essential amino acids lysine and methionine (Vaz & Wanders 2002, Shekhawat et al

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To specifically assess its neuroprotective effect in the SMA context, we used the transgenic model where smn-1 is specifically silenced only in 19 D-type MNs 27 , thus avoiding the pleiotropic effect of smn-1 depletion in all the organism (that on the contrary occurs in SMA patients)