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Nevertheless, as discussed above, an abnormal postmethionine-load homocysteine elevation above fasting levels must be taken into account in the general identification of patients bearing transsulfuration defects, such as vitamin B 6 -deficient subjects or heterozygotes for CBS deficiency

doi: 10.1038/s41467-021-27758-8 32 HuJ.TangJ.ZhangX.YangK.ZhongA.YangQ.et al

Important Safety Considerations Both NAC and glutathione are generally well-tolerated, but some precautions apply: NAC may interact with nitroglycerin and certain blood pressure medications