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Our observations suggest that pre-emptive genotyping of CYP2C9 and GSTM1 may aid in selection of more effective prophylaxis to reduce HC development in pediatric patients undergoing allogeneic HSCT

Longer term For longer protocols, review IGF-1 and metabolic trends periodically with a clinician

Among nonsteroidal anti-inflammatory drugs, aspirin dissociates mitochondrial-bound HK2 by disrupting its interaction with VDAC1, 1179 whereas diclofenac suppresses GLUT1 and HK2 activity, thus reducing glycolysis

ROS enhances inflammation by activating MAPK, which subsequently phosphorylates downstream proteins to upregulate the expression of pro-inflammatory genes such as IL-6, TNF-, and IL-1 [90]