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(100) subjected PS1 gene-knockin mice to continuous EODF for 3 months and found that the EODF group exhibited enhanced resistance to excitotoxic damage in hippocampal CA1 and CA3 neurons, with fewer lipid peroxidation products (4-hydroxy-2-nonenal) compared to the AL group, suggesting that inhibition of oxidative stress might be a potential mechanism for the neuroprotective effects of EODF

Hypoxia is also an active member of the niche microenvironment in regulating stem cell activities (Mohyeldin et al., 2010)

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