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The primary sequence and structure of the kappa class enzymes is more closely related to the prokaryotic disulphide-bond-forming oxidoreductase (DsbA) and 2-hydroxychromene-2-carboxylate isomerases than the mammalian cytosolic GSTs

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P.MenniC.TamrazB.WarehamN.KhawK.-T.et al (2019)

In a mouse model of colitis induced by dextran sulfate sodium salt, oral administration of baicalin solution (100 mg/kg) was shown to restore colon length and spleen index to near normal levels, alleviate ulcer severity, decrease the expression of CD14 and IL-6 in the colonic mucosa, reduce the binding of Toll-like receptor 4 (TLR4), and inhibit the activation of the myeloid differentiation primary response protein 88 (MyD88)/NF-B p65 pathway, and the positive control drug mesalazine showed similar protective effects, can effectively improve the main indicators of the disease, thus effectively exerting an anti-colitis effect (Fu et al., 2021)