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Based on these data, the FDA approved tesamorelin (marketed as EGRIFTA) for the reduction of excess abdominal fat in HIVassociated lipodystrophy, not as a general weightloss drug for the wider population. Tesamorelin Risks and Considerations Like all hormonemodulating therapies, tesamorelin carries potential risks, including fluid retention, joint pain, injectionsite reactions, and effects on glucose metabolism in susceptible patients

MOTS-C MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a naturally occurring peptide encoded within mitochondrial DNA, playing a key role in cellular metabolism and energy regulation

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