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Herein the formulation and processing parameters in the DoE (Table S3) included the ratio between mannitol and nanoparticle (w/w) (A), the atomization gas flow rate (L/h) (B), and the feed rate of solution during the spray drying process (mL/min) (C), while the responses included redispersibility of the dry powder (Z 1 ), PDI of the reconstituted nanosuspension (Z 2 ), and volumetric particle size of dry powder (m) (Z 3 )

Alteration of NMDA receptor numbers in chronic alcoholics is likely to be responsible for some of the symptoms seen in delirium tremens during severe alcohol withdrawal, such as delirium and hallucinations

doi: 10.1038/s41467-020-14389-8 14 PagoniPKorologou-LindenRSHoweLDDavey SmithGBen-ShlomoYStergiakouliEet al

doi: 10.1038/ni.3366 66 Gonzalez-HurtadoELeeJChoiJSelen AlperginESCollinsSLHortonMRet al