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Importantly, the gut symptoms (abdominal pain, diarrhoea, weight loss, low-grade fever, sometimes rectal bleeding) may or may not be present at the time the mouth changes appear

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Nature 380:435439 Henry TD, Annex BH, McKendall GR, Azrin MA, Lopez JJ, Giordano FJ, Shah PK, Willerson JT, Benza RL, Berman DS et al (2003) The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis

Due to the comparative small size of the rats and large size of the defects, these defects would fairly mimic large fistulas in patients that would hardly heal spontaneously