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Description

However, because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, published protocols consistently list active or precancerous conditions as contraindications requiring exclusion from study populations.

10.1371/journal.ppat.0030044 PLoS Pathog

USA 115 , E4661E4669 (2018)

And heres the critical point most people miss: DSIPs exact mechanisms of action remain unresolved , with species-specific effects that make extrapolation from animal studies to humans a problematic endeavor