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Points of departure were converted from administered animal doses to human equivalent doses (HEDs) using a standard body weight scaling factor (based on human body weight of 70 kg) in accordance with USEPA guidance (USEPA 2005a)

Studies have shown that environmental chemicals can disrupt the carefully orchestrated androgen-dependent processes essential for normal sperm development, from spermatogonial stem cell maintenance through final sperm maturation (68)

In this regard, the GIP and GLP-1 agonist, tirzepatide, currently shows promising data derived from phase 2 and 3 clinical trials

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