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Moreover, a cluster analysis of S-glutathionylated targets, which are known to play a role in apoptosis and inflammation according to the Gene Ontology (GO) collection or Kyoto Encyclopedia of Genes and Genomes (KEGG), revealed a putative overlapping association between Grx1 and neurodegenerative diseases (Gorelenkova and Mieyal, 2019)

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Its various mechanisms, including its antioxidant effects, the stimulation of pheomelanin synthesis instead of eumelanin, and interference with intracellular trafficking of melanogenic enzymes, contribute to its antimelanogenic properties.3 Hence, through the histopathological examination of melanocyte activity, location of melanin pigment deposition, and response after therapy, we can determine the effects of glutathione on skin color.6,9 However, Arjinpathana and Asawanonda1 reported many contradictory results regarding the efficacy and safety of glutathione as a skin-lightening agent