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Future studies should prespecify injected versus noninjected lesions, incorporate imaging criteria that account for pseudo-progression or mixed responses, and include pharmacodynamic endpoints confirming on-mechanism activation within the tumor, such as type I IFN signatures, dendritic-cell maturation markers (CD40, IL-12), and chemokine induction (CXCL9/10)

Do not inject the water directly onto the lyophilized powder

Rare side effects at very high doses may include skin breakouts or mild GI discomfort, but serious toxicity is not a practical concern for most people

Peat encouraged a high metabolic and low polyunsaturated fats diet