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Glutathione Metabolism Explained: The Master Antioxidant Scientists GSH GSSG Why it is important: The GSH GSSG ratio reports the reduced vs oxidized glutathione pool and is a sensitive marker of oxidative stress. Clinical and translational contexts include sepsis Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets: Cell Reports Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis Nature Chemical Biology
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