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a tumor such as a pancreatic adenocarcinoma tumor regression induced by employing the methods of this invention would be indicated by finding a decrease in any of the pro-angiogenic markers discussed above, an increase in anti-angiogenic markers described herein, the normalization (i.e., alteration toward a state found in normal individuals not suffering from cancer) of metabolic pathways, intercellular signaling pathways, or intracellular signaling pathways that exhibit abnormal activity in individuals diagnosed with cancer

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4-) Stephens FB1, Marimuthu K, Cheng Y, Patel N, Constantin D, Simpson EJ, Greenhaff PL

doi:10.5455/gulhane.240846 2Scully C, Eisen D, Carrozzo M