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Health economics Older adults living with severe obesity have increased healthcare use and cost [22], although the effect of obesity on years-of-life-lost is greatest in younger adults, and the magnitude of years lost with obesity decreases with ageing [16], irrespective of sex, smoking status, physical activity level, or socioeconomic status [35], complicating the health economic considerations of obesity management in older adults

Among these, withanolides a class of steroidal lactones such as withaferin A and withanone have been most thoroughly investigated for their anti-inflammatory, anticancer, and neuroprotective effects

While on a vacation to the Colorado Rocky Mountains during the Spanish flu pandemic of 1918, he became aware of the increased mortality of Spanish flu victims at higher altitude (