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Despite the limitations of the current evidence base such as small sample sizes, a lack of functional validation for identified genetic variants, and limited longitudinal data, this review opens new avenues for research

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Effects of mild, moderate, and severe renal impairment as well as end-stage renal disease not yet on dialysis on lomitapide exposure have not been studied [see Dosage and Administration (2.6) and Use in Specific Populations (8.6)]